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Hydrogel promotes wound healing better than traditional bandages, gauzes

Advances in hydrogel wound dressings make them antibacterial, biodegradable, better suited for healing irregular, deep wounds

Date:
February 16, 2021
Source:
American Institute of Physics
Summary:
For explosion wounds as well as some incurred in disasters and accidents, severe hemorrhage is a leading cause of death. Hydrogel dressings, which have advanced in recent years, may help; they are good at promoting wound healing and can better meet the demands of different situations. Many are antibacterial, biodegradable, responsive, and injectable and can fill irregularly shaped wounds.
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The widespread use of high-speed and high-energy weapons in modern warfare has led to an increasing incidence of explosive injuries. For such wounds as well as those incurred in disasters and accidents, severe hemorrhage is the leading cause of death.

In APL Bioengineering, by AIP Publishing, researchers from the Southern University of Science and Technology in China examine the advances in hydrogel dressings in recent years, which are good at promoting wound healing and can better meet the demands of different situations.

"With the rapid developments of material science, there are numerous highly efficient wound dressings being developed," said author Decheng Wu.

While bandages and gauzes are effective in controlling hemorrhage, they have various limitations. They are not biodegradable and are susceptible to infection and unsuitable for irregularly shaped wounds. They might also cause secondary tissue damage and are almost ineffective for wound healing.

Many hydrogel wound dressings are antibacterial, biodegradable, responsive, and injectable. Conventional dressings, in contrast, have a single function, making them less effective for wound treatment.

Hydrogel is a 3D network that is composed of hydrophilic polymers, which can absorb and swell in water. Hydrogels can be prepared by different cross-linking strategies, and they are classified in different ways based on their constitutes.

Polysaccharide-based hydrogels are biocompatible, biodegradable, and nontoxic. In contrast, synthetic polymer-based hydrogels are more easily modified and have better mechanical strength.

When used as a wound dressing, hydrogel not only forms a physical barrier and removes excess exudate but also provides a moisture environment that promotes the wound healing process. Additionally, hydrogel can perfectly fill irregularly shaped wounds and deal with deep bleeding efficiently.

The poor mechanical strength of existing hydrogel dressings limits their applications in the treatment of massive bleeding, such as arterial ruptures, since they cannot provide effective protection for the wound to prevent secondary damage. Consequently, the researchers will focus future research on developing hydrogel dressings with high mechanical strength so these dressings could help with fatal severe hemorrhage.

"Hydrogels are a kind of superior material," said Wu. "In my opinion, high-performance hydrogels also have potential in the field of tissue engineering to replace some tissues that can self-heal and regenerate, such as annulus fibrosus, meniscus, and cornea."


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Materials provided by American Institute of Physics. Note: Content may be edited for style and length.


Journal Reference:

  1. Zheng Pan, Huijun Ye, Decheng Wu. Recent advances on polymeric hydrogels as wound dressings. APL Bioengineering, 2021; 5 (1): 011504 DOI: 10.1063/5.0038364

Cite This Page:

American Institute of Physics. "Hydrogel promotes wound healing better than traditional bandages, gauzes." ScienceDaily. ScienceDaily, 16 February 2021. <www.sciencedaily.com/releases/2021/02/210216114953.htm>.
American Institute of Physics. (2021, February 16). Hydrogel promotes wound healing better than traditional bandages, gauzes. ScienceDaily. Retrieved October 31, 2024 from www.sciencedaily.com/releases/2021/02/210216114953.htm
American Institute of Physics. "Hydrogel promotes wound healing better than traditional bandages, gauzes." ScienceDaily. www.sciencedaily.com/releases/2021/02/210216114953.htm (accessed October 31, 2024).

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